Incurin Dosage Calculator for Dogs
Determine dosage guidelines based on your dog’s current stage of treatment.
Calculated Dosage Plan
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Urinary incontinence in female dogs, the low estrogen levels after hormonal changes often result in an embarrassing leakage of urine, particularly after spay surgery, and is a very common and frustrating problem. The positive aspect: this form of incontinence is very treatable. INCURIN® (estriol) Tablets is a veterinarian-prescribed estrogen replacement therapy containing the natural short-acting estrogen estriol that occurs in female dogs and is an effective choice for hormone-related problems with bladder control.
The results of clinical studies demonstrate that Incurin dosage for dogs is effective in reducing or completely eliminating urinary incontinence, with 93% of dogs treated with Incurin being improved or completely continent within 6 weeks, with one simple starting dose in all female dogs, removing the guesswork from treatment. Easy to administer in the tablet form by hiding in your pet’s favorite wet food or a pill pocket for stress-free, tasty on-schedule administration.
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Below, we’ll break down the recommended Incurin dosage for dogs, how it works, and what to expect once your pup starts treatment.
What is Incurin Dosage For Dogs?
The correct Incurin for dogs is not based on weight but is based on how your dog responds to Incurin. Oral administration is the recommended route and all dogs should be started on an initial dose of 2 mg (two 1 mg tablets) once a day for 14 days to control urinary incontinence.
The drug is then gradually decreased by the veterinarian once symptoms improve (typically 7 days at a time to a minimum of 1 mg or 0.5 mg a day), to find the lowest maintenance dose that is effective. Dogs should never be given more than 2 mg per day, so please check with your vet before changing your dog’s dose of Incurin.
Incurin Dosage Chart For Dogs By Weight
Here is the clear, structured dosage reference table for Incurin dose for dogs, based on standard veterinary administration protocols.
| Treatment Phase | Daily Dose | Administration | Frequency | Recommended Duration | Key Clinical Notes |
| Initial Therapy | 2.0 mg | 2 tablets (1 mg each) | Once daily | 14 days minimum | Starting dose for all dogs (not weight-dependent). Can give with or without food. |
| Maintenance: Step 1 | 1.0 mg | 1 tablet (1 mg) | Once daily | 7 to 14 days | Initiated once urine leaking stops to find the lowest effective maintenance dose. |
| Maintenance: Step 2 | 0.5 mg | ½ tablet (1 mg split) | Once daily | Long-term maintenance | Lowest standard dosage step to maintain baseline continence. |
| Dose Escalation / Recurrence | 2.0 mg | 2 tablets (1 mg each) | Once daily | 7 days (per vet direction) | Used if incontinence recurs at lower doses. Do not exceed 2.0 mg per day. |
Important Safety Guidelines
- Not Weight-Dependent: Starting and maintenance dosage adjustments are based on clinical response (continence), not body weight.
- Maximum Daily Limit: A dog should never exceed 2.0 mg per day. If 2.0 mg fails to control leaking after 14 days, consult your veterinarian for re-evaluation.
- Adjustment Interval: Allow a minimum of 7 days between any dosage reductions or adjustments.
What is Incurin Tablets for Dogs?
Incurin® is an FDA approved oral drug that treats urinary incontinence in spayed females due to estrogen deficiency, a condition that is particularly common in older spayed females. Hormone related incontinence is due to the lack of sufficient (or lack of) estrogen, a hormone that helps maintain urinary tract health. Dogs will urinate normally but may be leaking urine (and sometimes blood) when resting.
The active ingredient in Incurin is one of the naturally occurring, short acting estrogens of the female dog called estriol. Estriol dosage is used as a hormone replacement therapy that functions by fortifying the urethral sphincter muscle that controls urination from the bladder. This muscle weakens in low-estrogen dogs, causing leaks; Incurin restores the function of this muscle, and is effective in about 90% of dogs treated for urinary incontinence.
Incurin medication is not usually indicated for unspayed bitches and males since urinary incontinence is not associated with low level oestrogen in these cases. Also be aware that use of Incurin for other uses than for urinary incontinence is an “extra” or “off-label” use, which means that it has not been studied or approved by the FDA or Health Canada for such uses.
When this happens, it should be treated carefully and in accordance with the veterinarian’s individual directions and precautions, which may differ from the label instructions.
As urinary incontinence can have several causes, please check with your veterinarian before using Incurin to ensure you have the correct type of urinary incontinence and it is suitable for your dog.
Benefits of Incurin for Dogs
If your spayed female is wetting or leaks, discuss your dog’s need for estrogen with your veterinarian for a healthy urinary tract and to prevent “leaking” with an effective and well-tolerated prescription drug called Incurin.
Features and Benefits:
- Has been shown to decrease or eliminate urinary incontinence
- 93% of dogs treated were improved or continent by 6 weeks
- Convenient, once-a-day dosing
- One easy starting dose for every female dog – just 1 tablet size to keep on hand
- Dosage reduced to an effective level
- Estrogen-related side effects are minimized due to the fact that the receptor is only bound for a short time.
- Very well tolerated in a long-term (42 month) field study with 324 client owned ovariohysterectomised female dogs.
Possible Side Effects of Incurin for Dogs
When Incurin dog dosage is used at the right lowest effective dose, side effects are rare. Many side effects are only short term.
Common Side Effects:
- Reduced or lack of appetite (anorexia)
- Vomiting
- Increased thirst
- Increased urination
- Swollen vulva
- Increased vulva licking
- Anxiety
- Decreased energy
- Hair loss
- Drooling
If your dog has gastrointestinal or estrogenic symptoms or changes in color or texture of the vulva, contact your veterinarian.
Stop Medication and contact your veterinarian immediately:
- Suppression of the bone marrow (may manifest as lethargy, abnormal bleeding, bruising or fever)
- Seizures
- Mammary tumors
The action of this moderate-acting drug usually wears off in 24 hours, but it can be longer in dogs with liver or kidney disease.
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What Are the Most Serious Risks of Incurin for Dogs
Incurin has no serious side effects, as estriol is a short-acting estrogen, which is safer than other estrogen based products when used at the correct dosage. But there are some risks and precautions that need to be taken into account prior to usage.
Do NOT use Incurin in:
- Dogs with estriol allergy
- Dogs that are pregnant or nursing.
- Other estrogen containing treatments for dogs
- Any dog that exhibits more drinking and urination
- Male dogs
- Intact (unspayed) female dogs
- Under 1 year of age dogs
Caution: Use in:
- Dogs on glucocorticoid drugs
- Dogs that have a liver disease
- Dogs that have bone marrow depression
- Dogs that have mammary tumors.
Other risks and precautions:
- A full evaluation of factors contributing to urinary incontinence should be done before starting Incurin.
- Its use in combination with other estrogen containing drugs has not been studied and may lead to bone marrow suppression.
- Effectiveness when used concurrently with a glucocorticoid has not been demonstrated.
- Not studied in dogs with liver disease.
- Safe use has not been assessed in unspayed female dogs, pregnant or lactating dogs, male dogs or dogs less than 1 year of age.
- Depending on your dog’s condition, in some cases, Incurin can affect the thyroid hormone levels.
Does Incurin Interact with Other Dog Medications?
No drug interactions are currently documented for Incurin, but interactions may occur when Incurin pet dosage is used with some drugs and caution must be exercised when using Incurin with these drugs. Prior to beginning Incurin, inform your veterinarian of any medications, vitamins, supplements or herbal therapies your dog may be on.
Exercise caution when used with:
- Thyroid hormones
- Phenobarbital
- Ketoconazole
- Cimetidine
- Macrolide antibiotics (e.g., erythromycin)
- Cyclosporine
- Ursodiol
- Other estrogen therapy
It’s also recommended to avoid combining Incurin with medications that may suppress bone marrow.
Is Monitoring Needed with Incurin for Dogs?
Yes, it is important to monitor when using Incurin to make sure it is effective and safe.
- Your veterinarian will probably perform baseline bloodwork and a urinalysis prior to beginning estriol.
- Complete blood count should be performed two to four weeks after beginning use and should be checked every 3- to 6-months while the drug is being used.
- Your vet will let you know how and when to follow up to ensure your dog’s medication is working and has no unwanted side effects.
- Keep an eye on your dog at home to watch for any side effects. If any occur, discontinue the medication and call your veterinarian right away.
Incurin for Dogs: Important Safety Information
Incurin is labeled for spayed (ovariohysterectomized) female dogs for the control of urinary incontinence caused by the effects of estrogen. Factors causing urinary incontinence should be carefully assessed prior to initiating treatment.
Do not use Incurin:
- In combination with other estrogens or glucocorticoids (concomitant use has not been studied)
- In dogs that have polyuria (increased urination) because of polydipsia (increased water consumption)
- In pregnant dogs
The safety and effectiveness in these have not been assessed:
- Unspayed females (intact) dogs
- Male dogs
- Dogs that are used for breeding
- Dogs that are pregnant or lactating.
- Dogs less than 1 year of age
- Dogs that have liver disease.
The most common side effects reported:
- Loss of appetite (anorexia)
- Vomiting (emesis)
- Drinking too much water (poly-sipping)
- Swollen vulva
Additional Precautions:
- Not for human use. Store away from children.
- In pregnant or breast-feeding women, caution should be used when giving this medicine.
- Avoid exposure to the drug by washing hands with soap and water after administration.
- For complete prescribing information, refer to the product label.
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FAQs
What is the mechanism of action of Incurin and what are the advantages of taking it?
Incurin medicine acts by adding estrogen to the diet of spayed female dogs to help alleviate urinary incontinence that’s associated with low or no estrogen levels after spay surgery. It is approved by the FDA, it works for hormone related incontinence and is easy to take orally and is generally well tolerated.
How is Incurin given to dogs?
Incurin is taken by mouth once a day with or without food and the dose doesn’t depend on the weight of the person. The usual starting dose is 1 tablet (1mg) once a day for 7-14 days. If that is working, your vet might attempt to decrease to the lowest effective dosage; if that amount is ineffective, he or she would go back to the previous dosage that was effective.
May be increased to 2mg daily (for 7 days) under veterinary supervision if 1mg daily is ineffective. Always take veterinarian’s advice.
What kind of results can I get from Incurin treatment?
You should see improvement in your dog’s clinical symptoms, with urine leaking stopping altogether. Effectiveness is measured as being free from incontinence 7 days in a row; improvement is typically seen within a few days. Sometimes it takes a bit of tweaking to get the right dosage for your dog and treatment will likely need to be ongoing for the duration of its effectiveness.
What are the side effects and issues that my dog may have with Incurin?
Common side effects are loss of appetite, vomiting, thirst and a swollen vulva (in the females).
What is the treatment for Incurin and what are the precautions to be taken about using it?
Use gloves when handling Incurin as estriol is a reproductive risk for humans, and can be added risk to pregnant or breastfeeding women handling the medication.
What should I do if my dog misses a dose, or if there’s an emergency?
In the case of a missed dose, administer as soon as remembered and then resume the scheduled dose; if it is close to the time of the next dose, skip the missed dose and proceed with the next dose. If you suspect an overdose or adverse reaction, immediately contact your veterinary office or follow their instructions to contact an emergency facility in case they are not available.
Have information about the product, your dog’s weight and any symptoms your dog has developed and report any side effects to the FDA or Health Canada.
What are the instructions for storing Incurin and do you need to complete the entire course for your dog?
Keep commercially compounded tablets at a temperature of 77°F or less, in a tightly capped container, and compounded versions of the medication per label, and away from children and pets. The duration of treatment is dependent on the dog; ask a veterinarian if you have questions about length of treatment or stopping the treatment.
Will I get the exact same brand as shown and is Incurin a genuine brand name product?
Yes—in fact, Incurin is a brand, and you will get what you ask for—Incurin, the brand.
Key Takeaways
- Incurin (estriol) is for the treatment of urinary incontinence in female dogs related to estrogen.
- It comes in tablet form and is typically given once a day.
- Incurin dosage usually doesn’t cause significant side effects, but may cause loss of appetite and vomiting in some dogs.
Final Thoughts
Incurin is a drug that is effective in treating urinary incontinence associated with estrogen in female dogs. It is offered in tablet form and is usually administered once a day; however, the dosage amount will depend on your dog’s condition and will be determined by your veterinarian.
Though Incurin does pose a few light side effects, such as loss of appetite and vomiting, it can be very successful in fixing urinary incontinence and getting your dog back to a comfortable, dry and leak-free life.
