Fertagyl® Dosage Calculator
Off-label Canine Gonadorelin Volume Calculator
Fertagyl® (gonadorelin acetate) is a veterinary hormone drug approved for dairy cattle, not dogs. Veterinarians might use gonadorelin off-label in certain reproductive situations, and the correct dose, duration of treatment and follow-up will depend on the dog's condition, reproductive status and clinical judgment of the veterinarian. Fertagyl dosage for dogs should only be used by a pet owner under veterinary advice.
Fertagyl injectable solution contains 43 mcg of gonadorelin per mL, a synthetic form of gonadotropin-releasing hormone (GnRH). It acts by stimulating the pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH) which are hormones that cause the release of the egg and the luteinization process and are responsible for normal reproductive function.
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It covers all the information a dog owner must know about Fertagyl dosage for dogs, including off-label uses, dosage considerations, administration, expected effects, potential side effects, precautions, drug interactions, overdose symptoms and signs, and when veterinary care is warranted. In addition, you'll also discover a dosage calculator for dogs by weight, dosage chart, and helpful safety tips to better understand this medicine and provide your dog with the safest and most effective treatment.
What is Fertagyl Dosage For Dogs?
Fertagyl (gonadorelin) is an injectable solution that is FDA approved in cattle and is for off-label use in dogs. Reproductive theriogenologists use off-label micro-dosing protocols which have been derived from the standard US drug concentration of 43 mcg/mL. Dogs need very small volumes of fluid when compared to livestock, so doses should be carefully weighed and measured and are usually between 0.5 mcg/kg to 2.0 mcg/kg administered intramuscular (IM) using fine tuberculin or insulin syringes.
The high degree of accuracy needed and the possible risk of receptor desensitization make it advisable to calculate Fertagyl and administer it only under direct veterinary supervision.
Fertagyl Off-Label Dosage Chart For Dogs By Weight
Here is the off-label Fertagyl (Gonadorelin) reference dosage chart for dogs based on the standard US formulation of 43 mcg/mL.
Formulation Standard: 43 mcg/mL gonadorelin
Route of Administration: Intramuscular (IM) injection
Equipment: Use a 1 mL tuberculin (TB) syringe or insulin syringe for accurate measurement of small volumes.
| Dog Weight (lbs) | Dog Weight (kg) | Low Range Dose (0.5 mcg/kg) | Standard Dose (1.0 mcg/kg) | High Range Dose (2.0 mcg/kg) |
| 5 lbs | 2.3 kg | 0.03 mL (1.1 mcg) | 0.05 mL (2.3 mcg) | 0.11 mL (4.5 mcg) |
| 10 lbs | 4.5 kg | 0.05 mL (2.3 mcg) | 0.11 mL (4.5 mcg) | 0.21 mL (9.1 mcg) |
| 15 lbs | 6.8 kg | 0.08 mL (3.4 mcg) | 0.16 mL (6.8 mcg) | 0.32 mL (13.6 mcg) |
| 20 lbs | 9.1 kg | 0.11 mL (4.5 mcg) | 0.21 mL (9.1 mcg) | 0.42 mL (18.1 mcg) |
| 30 lbs | 13.6 kg | 0.16 mL (6.8 mcg) | 0.32 mL (13.6 mcg) | 0.63 mL (27.2 mcg) |
| 40 lbs | 18.1 kg | 0.21 mL (9.1 mcg) | 0.42 mL (18.1 mcg) | 0.84 mL (36.3 mcg) |
| 50 lbs | 22.7 kg | 0.26 mL (11.3 mcg) | 0.53 mL (22.7 mcg) | 1.05 mL (45.4 mcg) |
| 60 lbs | 27.2 kg | 0.32 mL (13.6 mcg) | 0.63 mL (27.2 mcg) | 1.27 mL (54.4 mcg) |
| 70 lbs | 31.8 kg | 0.37 mL (15.9 mcg) | 0.74 mL (31.8 mcg) | 1.48 mL (63.5 mcg) |
| 80 lbs | 36.3 kg | 0.42 mL (18.1 mcg) | 0.84 mL (36.3 mcg) | 1.69 mL (72.6 mcg) |
| 90 lbs | 40.8 kg | 0.47 mL (20.4 mcg) | 0.95 mL (40.8 mcg) | 1.90 mL (81.6 mcg) |
| 100 lbs | 45.4 kg | 0.53 mL (22.7 mcg) | 1.05 mL (45.4 mcg) | 2.11 mL (90.7 mcg) |
Important Clinical Notes
- Mathematical Formula: Volume (mL) = [Weight (kg) * Target Dose (mcg/kg)] / 43 mcg/mL
- Off-Label Notice: Fertagyl is approved for cattle and is not FDA-approved for dogs. Exact dosage and administration must be determined by a qualified reproductive veterinarian.
What Is Fertagyl for Dogs?
Fertagyl for dogs refers to the off-label application of Fertagyl® (gonadorelin acetate) a prescription hormonal injectable drug that contains 43 mcg of gonadorelin per mL. It is FDA approved for treating cystic ovaries and estrous synchronization in dairy cattle; however, veterinarians can prescribe it for certain reproductive cases in dogs as clinically appropriate.
Gonadotropin-releasing hormone (GnRH) is a naturally occurring hormone; Gonadorelin is a synthetic version of this hormone. It acts on the pituitary gland to enhance the production of two hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which play a role in the reproductive cycle, resulting in ovulation, maintaining ovarian function and boosting fertility.
Off-label uses of Fertagyl medication in dogs include ovulation induction, some fertility and breeding problems, to facilitate breeding dates and/or artificial insemination, and to treat or evaluate specific reproductive disorders. Fertagyl should only be used under the direction of a veterinarian experienced in canine reproduction since these uses are not listed on the approved label.
Fertagyl medicine comes as a sterile injectable solution and should be used under the veterinary's prescription. The correct dose and duration of treatment will vary based on the dog's health status, breeding program or reproductive status. Fertagyl must never be used without veterinary advice or by following cattle dosing instructions on dogs – this will not be safe and could lead to unsuccessful treatment or to hormonal problems.
Is Fertagyl Approved for Dogs?
Fertagyl® is not approved to use in dogs. Fertagyl (gonadorelin injection 43 mcg/mL) has been approved by FDA for use in dairy cattle to treat cystic ovaries and to synchronize the estrous cycle to facilitate fixed-time (FTAI), in combination with the use of cloprostenol products (ESTRUMATE® or cloprostenol sodium) in dairy and beef cattle.
Fertagyl does not have an approved label indication in dogs and is classified as an "off label" pharmaceutical, which means it is used for certain reproductive purposes by a veterinarian if appropriate for clinical need. Use in dogs should only take place under the supervision of a licensed veterinarian experienced in canine reproduction.
What Does Fertagyl (Gonadorelin) Do in Dogs?
Fertagyl® (gonadorelin injection 43 mcg/mL) is not approved by the FDA for use in dogs, but may be used off label for certain reproductive conditions at the discretion of the veterinarian. Fertagyl is based on the synthetic form of gonadotropin-releasing hormone (GnRH) secreted naturally by the hypothalamus, called gonadorelin.
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When injected into muscles or veins, it stimulates the anterior pituitary gland to release the reproductive hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones aid in maintenance of reproductive cycle and normal fertility functions.
In dogs, Fertagyl may help:
- Encourage the release of LH and FSH
- Aid female ovulation
- Support luteinization (corpus luteum formation post ovulation)
- Maintain normal reproduction hormone levels
- Support veterinarians in the off-label management of selected reproductive and breeding related conditions
- Promote fertility control under veterinary care
Fertagyl dog dosage is not approved for use in dogs and its dose and treatment regime should always be decided upon by a licensed veterinarian with experience in canine reproduction.
Fertagyl (Gonadorelin) Overdose in Dogs: What Should You Do?
Fertagyl® (gonadorelin) is not licensed for use in dogs, but if a large overdose or incorrect use occurs you should seek veterinary advice immediately.
If you suspect your dog has received too much Fertagyl:
- Call your vet right away for medical advice.
- The sooner you get your dog to the closest emergency pet hospital the better, particularly if they don't look well.
- Only additional doses should be administered when directed by your veterinarian.
- Know exactly what it was, the time it happened, and your dog's size and signs of illness to assist in treatment.
- In the event of an adverse experience with the product, you can also call Merck Animal Health Pharmacovigilance – Companion Animal Technical Services (Dogs & Cats): 800-224-5318. 800-211-3573 is a livestock technical assistance number.
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FAQs
Is it safe to use Can Fertagyl in dogs?
However, it is only used as an "off label" drug, prescribed by a veterinarian for specific reproductive problems. Not approved for use in dogs by FDA.
What Does Fertagyl Do for Dogs?
Fertagyl can be used to stimulate ovulation, address certain fertility problems, breeding programmes and to help control reproductive hormones in some situations, under veterinary advice.
What Does Fertagyl Do For Dogs?
Fertagyl is a synthetic form of gonadotropin-releasing hormone (GnRH) and has a gonadorelin content. It acts on pituitary gland and drives the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) which aids in regulating reproductive function and ovulation.
How Does Fertagyl Work on Dogs?
Fertagyl dosage is given as an injectable medication. Dosage, method of administration and duration of treatment should always be prescribed by a licensed veterinarian, depending on the dog's reproductive status.
What are the Side Effects of Fertagyl in Dogs?
Fertagyl dosage for dogs is very safe to use with few side effects when used properly under veterinary supervision. But it should always be watched to see if there are any unusual responses following injection, and any concerns should be notified to the veterinarian prescriber as soon as possible.
Is Be Used to Can Fertagyl Dogs?
Fertagyl should not be used in pregnant dogs unless, in the vet's opinion, the benefits outweigh the risks. It should be used with caution by professionals when a woman is pregnant.
If I forget to take a dose of Fertagyl what should I do?
In case your dog does not receive the necessary Fertagyl injection at the appointed time, please contact the veterinarian for instructions. Never give a double dose or change the dose schedule without veterinary advice.
Is It Safe To Mix Can Fertagyl With Other Reproductive Drugs?
May be used with other reproductive drugs as directed by a veterinarian, but any combination must be used under the guidance of a veterinarian to ensure safety and effectiveness.
Key Takeaways
- Fertagyl® (gonadorelin) is not approved by the FDA for use in dogs and is used "off-label" in dogs and should only be directed by a licensed veterinarian.
- The drug has a concentration of 43 mcg/mL gonadorelin, a synthetic form of gonadotropin-releasing hormone (GnRH), which is a hormone that promotes the release of LH and FSH that is necessary for normal reproductive function.
- Fertagyl can be used in dogs for certain reproductive and breeding-related ailments and the dose is tailored to the dog.
- Fertagyl is used as an injection and can only be applied by a veterinarian.
- Cattle dosing guidelines are not suitable for dogs, so do not use these guidelines.
- Be sure to watch your dog for any abnormal behavior following treatment and call your veterinarian immediately in case of an overdose or untoward effects.
- The use of Fertagyl should only be considered if the potential benefits justify the risks, such as when used for breeding/reproductive management purposes.
- Always follow your veterinarian's treatment plan and never begin, stop or change Fertagyl therapy without your veterinarian's advice.
Final Thoughts
Although not FDA labelled for use in dogs, Fertagyl® (gonadorelin) is a useful off-label drug for specific reproductive conditions in dogs when used under a veterinarian's supervision. Since it directly influences reproductive hormones, it is important to apply the correct dose, time and monitor for safe and effective treatment.
When your veterinarian recommends Fertagyl dosage for dogs, follow your veterinarian's recommendations precisely and do not use livestock dosing guidelines for dogs. Also, it's crucial to seek veterinary advice immediately if you miss a dose, encounter any unexpected side effects, or suspect an overdose. When used under veterinary supervision, Fertagyl can be used as a way of supporting reproductive management in certain dogs whilst reducing potential complications.
