Simparica Trio Dosage Calculator For Dogs
Calculate the appropriate Simparica Trio tablet strength based on your dog’s body weight. This calculator follows the FDA-approved weight ranges. Tablets should never be split or broken.
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It’s important to find the correct Simparica Trio dosage for dogs so your pet gets the protection necessary to fight some of the most common and potentially serious parasites. Simparica Trio is a monthly chewable tablet approved by the FDA, and intended for use in dogs only. It is a combination of sarolaner, moxidectin and pyrantel in one product for broad-spectrum protection against fleas, ticks, heartworm disease, roundworms and hookworms.
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Simparica Trio is a single chew combination that provides complete protection against parasites, unlike Simparica which only protects against fleas and ticks. Once a month, the tablet is administered with or without food; always based on the current body weight of the dog.
It can be given to puppies and dogs 8 weeks old or older weighing 2.8 pounds/1.3 kg or more, and tablets should not be broken or split. Each strength is formulated to provide the suggested minimum levels of all three active ingredients, for safe and effective parasite control.
Simparica Trio for dogs does more than just treat flea infestations, it helps kill the fleas before they can lay eggs and prevent flea infestations. Works against several types of ticks, such as the American dog tick, Black-legged (deer) tick, Brown dog tick, Lone Star tick, and Gulf Coast tick; in labeled use (where applicable), the Asian longhorned tick.
It also helps control tick populations, which in turn helps reduce the risk of numerous diseases spread by ticks, such as Lyme disease spread by the black-legged tick. It also helps to prevent heartworm disease and to treat and control common parasites like roundworms and hookworms in the intestine, making it one of the most comprehensive parasite prevention products on the market for dogs.
This resource will detail the official Simparica Trio dosage chart for dogs by weight, how to take the chew correctly, age and weight requirements, what to do if a dose is missed, possible side effects, safety precautions, and answer some frequently asked questions. From small puppies to large adult dogs, knowing the correct dosage can help keep your pet safe throughout the year and lessen the possibility of preventable parasite infections.
Key Takeaways
- Simparica Trio dosage for dogs is a prescription-only, once monthly chewable tablet which contains sarolaner, moxidectin and pyrantel to help protect dogs from many parasites.
- It helps prevent heartworm disease, can kill fleas before they lay eggs, and kill several species of ticks, treat and control roundworms and hookworms.
- Simparica Trio dosage for dogs depends solely on your dog’s present body weight. Always use the appropriate tablet strength – do not split or break a tablet.
- Simparica Trio is approved for dogs and puppies at least 8 weeks old that weigh 2.8 lb (1.3 kg) or more.
- Chewable tablet may be administered with or without food and once a month, preferably at the same time of the month.
- For dogs over 132 lb (60 kg), the proper combination of tablet strengths should be used as directed by the veterinarian.
- Simparica Trio dose for dogs is considered to be a rescue treatment and should be preceded by a heartworm test in dogs that might be infected with heartworms.
- Dogs with a history of seizures or neurological disease should use Simparica Trio with caution as it contains isoxazoline (sarolaner) which has been linked to neurological reactions in some dogs.
- In the event of a missed dose, Simparica Trio should be administered as soon as possible and then at the same time every month.
- Consult with your veterinarian before changing, starting or stopping any parasite control program.
Simparica Trio Dosage Chart for Dogs By Weight
| Dog Weight | Dog Weight | Tablet Strength | Sarolaner | Moxidectin | Pyrantel (as pamoate) | Number of Tablets |
|---|---|---|---|---|---|---|
| 2.8–5.5 lb | 1.3–2.5 kg | Yellow | 3 mg | 0.06 mg | 12.5 mg | 1 tablet |
| 5.6–11 lb | 2.6–5 kg | Purple | 6 mg | 0.12 mg | 25 mg | 1 tablet |
| 11.1–22 lb | 5.1–10 kg | Brown | 12 mg | 0.24 mg | 50 mg | 1 tablet |
| 22.1–44 lb | 10.1–20 kg | Orange | 24 mg | 0.48 mg | 100 mg | 1 tablet |
| 44.1–88 lb | 20.1–40 kg | Green | 48 mg | 0.96 mg | 200 mg | 1 tablet |
| 88.1–132 lb | 40.1–60 kg | Blue | 72 mg | 1.44 mg | 300 mg | 1 tablet |
| Over 132 lb | Over 60 kg | Combination of appropriate tablet strengths | Varies | Varies | Varies | As directed by a veterinarian |
Administration Notes
- Give one chewable tablet orally once every month.
- Select the tablet based on your dog’s current body weight.
- Do not split or break Simparica Trio tablets.
- Dogs must be at least 8 weeks old and weigh at least 2.8 lb (1.3 kg).
- Tablets may be given with or without food.
- If your dog weighs more than 132 lb (60 kg), use the appropriate combination of tablet strengths as recommended by your veterinarian.
- If a monthly dose is missed, administer it as soon as possible and continue the regular monthly dosing schedule.
What Is Simparica TRIO?
Simparica TRIO dosage for dogs is a once-monthly, liver flavored, chewable tablet for dogs that is only available with a veterinarian’s prescription and is effective against several different parasites with a single dose. It contains three active ingredients that can prevent heartworm disease, kill fleas before they lay eggs, prevent against several species of ticks and treat and control roundworms and hookworms. It is also marked for protection against flea tapeworms, which is done by effective flea control.
Simparica TRIO medication can be used in dogs and puppies 8 weeks and older and 2.8 lbs/1.3 kg or heavier. The chewable tablet can be given with or without food and research has found 9 out of 10 dogs would eat the flavored chew, allowing easy and convenient monthly administration for many pet owners.
Clinical studies demonstrate that Simparica TRIO starts killing fleas within 4 hours and is 100% flea killing within 8 hours, preventing them from laying eggs and decreasing the risk of a flea infestation. It was also the first FDA-approved combination parasite preventive that is proven to kill six species of ticks, including the black-legged (deer) tick which can transmit Lyme disease.
Simparica TRIO dose is the only veterinarian-prescribed combination parasite preventive recognized to protect over 15 million dogs. It provides full protection against parasites every month with a single bite, which is ideal for dog owners looking for an all-in-one flea, tick, heartworm and intestinal worm treatment. Check with your vet about the use of Simparica TRIO for your dog.
Benefits of Simparica TRIO for Dogs
Simparica TRIO is a one-time, monthly chewable that offers “all-in-one” broad-spectrum parasite protection. It is aimed at shielding dogs from heartworms, fleas, ticks, roundworms and hookworms without having to take the dogs multiple parasite medicines. It can be given with or without food, and is convenient to use all year round, being approved for dogs and puppies 8 weeks and older, weighing 2.8 lb (1.3 kg) or more, and flavored with tasty, liver-flavored chew.
Key Benefits
- Helps prevent heartworm disease; studies have shown 100% protection when applied as directed.
- Kills the flea before it can start laying eggs, preventing flea infestations and minimising the risk of flea tapeworm.
- Effective at killing 6 species of ticks: Gulf Coast, Black-legged (deer), American dog, Lone Star, Brown dog and Asian longhorned ticks.
- Treats and controls roundworms and hookworms which are two common intestinal parasites found in dogs.
- Easy to dose one chewable tablet once per month.
- Palatable liver flavored chew that many dogs will eat.
- With 100% satisfaction guarantee on prevention.
How Simparica TRIO Works
Simparica TRIO for dogs has a combination of three active ingredients that provide protection against various types of parasites:
- Sarolaner kills fleas and ticks by disrupting their nervous system.
- Moxidectin works by paralyzing and killing heartworm parasites that are susceptible to it.
- Pyrantel pamoate does not kill the worm, but rather causes them to become paralyzed so that they will come out through natural elimination.
This three-in-one formula in a single monthly chew gives pet owners complete protection against parasites, and makes it easier to keep their pet protected all year round.
What Is Simparica Trio Used for in Dogs?
Simparica Trio dosage for pets is a once monthly, prescription-only, chewable tablet which is broad-spectrum for parasites in dogs. It contains sarolaner, moxidectin and pyrantel, which are used to treat external and internal parasites, such as fleas, ticks, heartworms and intestinal worms. Approved by FDA for use in dogs and puppies that are 8 weeks of age or older and 2.8 lb (1.3 kg) or more.
Simparica Trio is used to:
- Protect against heartworm disease, which is caused by Dirofilaria immitis.
- Treat and prevent flea infestations by killing adult fleas before they can lay eggs.
- Prevent and manage ticks (Gulf Coast, black-legged (deer), American dog, Lone Star, Brown dog, and Asian longhorned).
- Treat and control roundworm and adult hookworm infections.
- Keep fleas from getting on your pet, as they are necessary for tapeworm transmission, to help reduce the risk of tapeworms.
How Simparica Trio Works
Simparica Trio contains three active ingredients each of which kills a specific group of parasites:
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- Sarolaner works by killing fleas and ticks.
- Moxidectin is a prevention for heartworm disease.
- Pyrantel treats and controls roundworms and hookworms.
Simparica Trio (when given once monthly) offers a complete control solution against parasites with one chew. Clinical trials indicated 100% protection against heartworm disease when used according to the manufacturer’s directions. Since the chewable tablet can be administered with or without food, monthly parasite control is easy and convenient for dog owners.
Possible Side Effects of Simparica Trio for Dogs
When used as directed, Simparica Trio is generally well-tolerated among most dogs. However, as with all medicines, it can have side effects in some canine. Reactions are often mild and short-lived, but in rare instances, serious neurological reactions have been reported as sarolaner is part of the isoxazoline class of drugs.
Common Side Effects
The most common side effects in clinical trials are:
- Vomiting
- Diarrhea
- Lethargy (low energy)
- Not eating (anorexia)
Rarer side effects can be:
- Hyperactivity
- Increased thirst (polydipsia)
- Increased urination (polyuria)
- Ear infections
- Itching
Neurological Side Effects
Simparica Trio contains an isoxazoline compound called sarolaner, which has been linked to neurological side effects in a small number of dogs. Such reactions have been seen in dogs with and without a previous neurological history, and dogs with a history of seizures may be more prone to these reactions.
Possible neurological side effects include:
- Muscle tremors
- At co-ordination (ataxia)
- Seizures
As a result of this risk, Simparica Trio should be used with care in dogs with a history of seizures, or any other neurological condition, and any concerns with use prior to treatment discussed with your veterinarian.
Important Safety Precautions
- Do not use on humans. Don’t let children handle Simparica Trio.
- Simparica Trio has not been tested in breeding, pregnant, or lactating dogs.
- Isoxazoline drugs have been associated with neurological reactions, but the FDA believes that these medications are safe and effective when used as directed in the approved drug labels.
- If your dog experiences any of the following side effects, and the symptoms do not improve, contact your veterinarian promptly: If your dog begins to develop persistent vomiting, diarrhea, unusual behavior, tremors, seizures or any other unexpected side effects after Simparica Trio, contact your veterinarian promptly.
What Is the Most Important Thing You Should Know About Simparica TRIO?
Simparica TRIO is a chewable tablet that treats dogs and puppies 8 weeks of age or older, and 2.8 lb/1.3 kg or more, and is a prescription-only, once-monthly medication. Helps protect against heartworm disease caused by Dirofilaria immitis, is effective against adult fleas, treats and prevents flea infestations, treats and controls tick infestations, treats and controls roundworm and adult hookworm infections for 1 month.
Before Giving Simparica TRIO
To begin taking Simparica TRIO, consult with your veterinarian about your dog’s health history. Important considerations include:
- Heartworm testing: It is important to test dogs for the presence of an existing heartworm infection prior to starting Simparica TRIO.
- Pregnancy, lactation or intended for breeding: If your dog is pregnant, lactating, or is to be used for breeding, tell your veterinarian since the safety of Simparica TRIO has not been determined in these dogs.
- Allergies: If your dog is allergic to any of the ingredients, tell your veterinarian.
Parasites Simparica TRIO Protects Against:
Simparica TRIO treats:
- Prevent heartworm disease.
- Eradicate adult fleas and treat and prevent flea infestations.
- Treat and control infestations of Lone Star, Gulf Coast, American dog, Black-legged (deer), and Brown dog ticks.
- Treat and control roundworms (Toxocara canis and Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala).
When used as directed by your veterinarian, Simparica TRIO offers monthly protection against some of the most common and important parasites for dogs.
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FAQs
If you forget to give Simparica Trio, what should you do?
If you miss a monthly dose, give Simparica Trio as soon as you remember and then continue the regular monthly dosing schedule. In the event your dog has not been protected for a while, talk to your vet because a heartworm test may be indicated prior to continuing treatment.
If my doggies up or vomits the tablet, what should I do?
If your dog vomits or spits out the chew soon after it’s administered, give another complete dose as soon as you can. After that, resume regular monthly administrations. If your dog continues to vomit, contact your veterinarian.
What if I give Simparica Trio dosage to my dog too often?
With an overdose, there can be increased risk of side effects like vomiting, diarrhea, lethargy, excessive drooling, muscle tremors, trouble with coordination or seizures. Contact your vet or take your dog to an emergency vet clinic right away if you think your dog may have ingested too much Simparica Trio.
May Simparica Trio be administered with food?
Yes. Simparica Trio can be used with or without food. The key is to make sure that your dog swallows the whole chewable tablet.
Are Simparica Trio tablets divided dose?
Simparica Trio tablets are not scored and should never be split, broken or divided. Always use the correct body weight/strength of tablet which your dog is in now.
Is it safe to use Simparica Trio in combination with other flea, tick or heartworm treatments?
Additional parasite preventives aren’t usually necessary, especially since Simparica Trio already protects against fleas, ticks, heartworms, roundworms and hookworms. Please consult your veterinarian before using in combination with other medications since studies examining the effects of using it concurrently with similar preventive measures are limited.
Is Simparica Trio safe for any breed of dog?
Simparica Trio is indicated to treat dogs and puppies 8 weeks old or older and weighing 2.8 lb (1.3 kg) or more. Not for use in cats and safety has not been determined for breeding, pregnant or lactating dogs. Do not use it unless under veterinary supervision for dogs with a history of seizures and/or neurological disorders.
Before starting Simparica Trio, should I have my dog tested for heartworm?
Yes. Before dogs begin Simparica Trio, it is important to have them tested to see if they are already infected with heartworm. The need for testing will depend on your dog’s age, health and previous history of heartworm prevention.
Under which condition Simparica Trio should be stored?
Keep Simparica Trio out of reach of children and pets and store in a dry place at or below 30°C (86°F) until it is time to give the medicine.
Can you buy Simparica Trio over the counter?
No. Simparica Trio is available by prescription only. The choice of which one to use depends on your dog’s age, weight, health status and risk of exposure to parasites and will be determined by your veterinarian.
Final Thoughts
With such a variety of different diseases to prevent, selecting the correct Simparica Trio dosage for dogs is critical to ensure year-round protection that is safe and effective. Since the dose of the medication depends on your dog’s actual weight, please use the correct tablet strength and follow the dosage instructions every month. Do not cut tablets in half or give a dosage for another weight range.
Simparica Trio dosage for dogs is well tolerated by many dogs, but each one is an individual. However, be alert to any abnormal responses that may occur after giving the medication and talk to your veterinarian if you are at all concerned, or if your dog has other medical conditions, a history of seizures, or a history of neurological diseases.
If used correctly and combined with other veterinary care measures, Simparica Trio is a valuable and convenient method for keeping your dog protected from a variety of common parasites year-round.
