K9 Advantix II Dosage Calculator For Dogs
Determine the precise dosage band and application instructions for your dog.
Dosage & Application Plan
- NEVER use this product on cats. Even a small amount of permethrin can be fatal to felines. Keep treated dogs separated from cats until the product is completely dry.
- Fixed-Dose System: Do not split tubes/vials between multiple dogs or attempt to guess partial doses, as active ingredient concentrations differ across package sizes.
- Apply the entire tube directly to the skin along the spine from the shoulder to the base of the tail as indicated above.
K9 Advantix II Dosage For Dogs is a veterinarian-recommended, dog owner trusted formula that begins to work within hours of application and kills most fleas within 12 hours, while also preventing new fleas from infesting the dog by inhibiting the flea life cycle. Regular monthly treatment can also help prevent issues related to flea infestations, like flea allergy dermatitis, flea bite anemia and tapeworm transmission, and prevent diseases transmitted by ticks, such as Lyme disease, ehrlichiosis, Rocky Mountain spotted fever and tick paralysis. The topical, fragrance-free formula is simple to use, waterproof after 24 hours, and is sold OTC (over the counter).
In this ultimate guide, you will find the proper dosage chart for K9 Advantix II for dogs by weight, safe application instructions, typical effectiveness, potential side effects, precautions and tips, and answers to commonly asked questions. An easy-to-use K9 Advantix II Dosage Calculator is also included to help you determine the correct size to use for your dog. Always apply the formulation required for your dog’s age (dogs and puppies 7 weeks of age and older) and weight; do not use the formulation on cats as the permethrin contained in K9 Advantix II is very toxic to cats.
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What is K9 Advantix II Dosage For Dogs?
K9 Advantix II for dogs is a topical monthly flea and tick treatment which is formulated using a fixed-dose system to ensure it is applied exactly to your dog’s body weight and not based on a formula calculation. Each pre-measured tube contains the active concentration that your pet requires based on its size and is available in a variety of colors: Green – Small Dogs (4-10 lbs), Teal – Medium Dogs (11-20 lbs), Blue – Large Dogs (21-55 lbs), Red – Extra Large Dogs (over 55 lbs). K9 Advantix II is safe for dogs and puppies 7 weeks of age and 4 lbs. or more, and is not to be split between dogs or used on cats.
K9 Advantix II Dosage Chart For Dogs By Weight
Here is the quick-reference dosage chart for K9 Advantix II:
| Dog Weight Range | Package / Box Color | Vial Size (Dose Volume) | Application Method (Along Spine) |
| 4 to 10 lbs (1.8 to 4.5 kg) | Green Box (Small) | 0.4 mL | Apply entire tube to 2 to 3 spots |
| 11 to 20 lbs (5 to 9 kg) | Teal Box (Medium) | 1.0 mL | Apply entire tube to 2 to 3 spots |
| 21 to 55 lbs (9.5 to 25 kg) | Blue Box (Large) | 2.5 mL | Apply entire tube to 4 to 6 spots |
| Over 55 lbs (Over 25 kg) | Red Box (Extra Large) | 4.0 mL | Apply entire tube to 4 to 6 spots |
Important Safety Checklist
- Age Limit: Dog must be at least 7 weeks old.
- Minimum Weight: Dog must weigh at least 4 lbs (1.8 kg).
- Cat Warning: NEVER use on cats. Permethrin is extremely toxic to felines and can be fatal. Keep treated dogs separated from cats until the application site is completely dry.
- Fixed Dosing: Always use the exact weight-band box. Never split single tubes between multiple dogs or guess partial doses.
What Is K9 Advantix II?
K9 Advantix II is veterinarian recommended once-monthly topical parasite preventative for dogs and puppies 7 weeks of age and older that weigh 4 pounds or more. Three active ingredients—the insecticide imidacloprid, the insecticide/repellent permethrin and the insecticide pyriproxyfen—have been combined to kill and repel fleas, ticks, mosquitoes, biting flies, and chewing lice and prevent infestations by targeting adult fleas, flea eggs, and flea larvae. The treatment takes action immediately on contact, meaning that parasites don’t have to bite or ticks have to attach to the dog before they die.
K9 Advantix II work by begins to act in hours, kills most adult fleas within 12 hours, starts killing attached ticks within 24 hours and will keep working and protecting for 30 days. It helps prevent flea allergy dermatitis, flea bite anemia and transmission of tapeworms and ticks which cause diseases like Lyme disease, ehrlichiosis, Rocky Mountain spotted fever and tick paralysis, and repels mosquitoes that transmit heartworms.
Easy to apply, safe for both indoor and outdoor dogs, no prescription required, waterproof (after 24 hours), spot-on treatment and fragrance free is well tolerated when used as directed. K9 Advantix II contains permethrin and should NOT be used at all on cats as it is highly toxic to them.
Benefits of K9 Advantix II for Dogs
K9 Advantix II medication is a veterinarian-prescribed topical treatment that offers quick, effective and long-lasting protection against multiple external parasites, monthly. It eliminates and deters pests so they don’t bite and leave your dog feeling great without putting him at risk of diseases and skin issues caused by parasites.
Key benefits include:
- Kills and repels fleas, ticks, mosquitoes, biting flies and chewing lice on contact.
- Kills all stages of flea (eggs, larvae, pupae and adults) which helps to stop the flea life cycle and stop new infestation.
- Destroys major tick species: Deer ticks, American dog ticks, Brown dog ticks and Lone Star ticks.
- Quickly active and kills fleas in 12 hours with up to 30 days (4 weeks) continuous protection.
- Promotes a decrease in itching, scratching, irritation and discomfort from flea and insect bites.
- Waterproof after 24 hours, effective after bathing, swimming, rain, normal outdoor activities, easy to apply and fragrance-free.
- Offers a variety of different formulations based on the weight of a dog and is not prescription only.
K9 Advantix II for dogs works quickly, has a wide spectrum of activity against parasites and is easy to apply once a month, providing a dependable solution to the problem of common biting insects that affect dogs, as well as year-round flea and tick protection.
How Does K9 Advantix II Work?
K9 Advantix II is effective through a combination of three active ingredients, imidacloprid, permethrin and pyriproxyfen, to help protect against fleas, ticks, mosquitoes, biting flies and chewing lice once a month. Once the topical solution is applied to your dog’s skin, the active ingredients spread throughout the skin and coat, and work to kill and repel parasites on contact, meaning that fleas and ticks don’t have to bite or attach in order to be impacted.
Each ingredient has a specific role:
- Imidacloprid works by disrupting the nervous system of fleas and lice causing them to become paralyzed and die.
- Permethrin is effective against ticks and other insects by disrupting the nerve cells on contact and is also insecticidal against biting flies, mosquitoes and repels ticks.
- Pyriproxyfen is an insect growth regulator (IGR) that stops the development of egg and larval fleas into adult fleas to help stop the flea life cycle and stop re-infestation.
K9 Advantix II dosage for dogs works at several stages of the life cycle of the parasites and is effective against them in different ways; thus offering a fast, thorough and long-lasting protection that lasts up to 30 days with just one application.
Potential Side Effects of K9 Advantix II for Dogs
When used in the recommended manner, K9 Advantix II is generally well tolerated; however, some dogs might experience mild to moderate side effects, especially immediately following application. While most reactions are temporary, after every reaction, your dog should be monitored, particularly within 24-48 hours of the treatment.
Some of the side effects are:
- Redness, itching, scratching, burning, tingling, numbness or discomfort at the site of application.
- Light hair thinning around the area treated.
- Vomiting, diarrhea or excessive salivation (particularly if licked or touches mouth).
- Some dogs may appear lethargic or agitated.
Any topical pesticide product can have individual sensitivities, although they are uncommon. If a rash persists for more than a few hours, or more than 3 days, or if your dog experiences any other serious symptoms such as excessive drooling, severe vomiting or diarrhea, please consult your veterinarian right away.
In case of an adverse reaction:
- Discontinue use of the product.
- Use a detergent-type dish soap (Dawn or Palmolive) to clean your dog, but avoid scrubbing skin.
- If symptoms are severe or you think there has been an overdose, contact your veterinarian or an emergency animal poison service.
Do not use K9 Advantix II in dogs that are younger than 7 weeks of age, less than 4 pounds, or have a known allergy to any ingredient of K9 Advantix II. Caution in underweight, elderly, frail, breeding, pregnant or nursing dogs. Do not use on cats also because K9 Advantix II contains Permethrin which is highly toxic for cats. For 24 hours following treatment: Keep treated dogs away from cats to avoid accidental exposure.
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Cautions When Using K9 Advantix II
K9 Advantix II may be applied externally to dogs only and should be applied as indicated on the product label. Permethrin found in K9 Advantix II is highly toxic and is fatal to cats, so NEVER use on a cat. Do not let cats come in contact with treated dogs for 24 hours following treatment and if ingestion occurs, a veterinarian should be contacted immediately.
Important precautions to follow:
- Only use on dogs and puppies 7 weeks or older that weigh 4 lbs. or more.
- Do not use on animals other than dogs.
- Do not get in the eyes or mouth of the dog.
- After use some dogs, especially small and medium sized, might experience skin irritation or some individual sensitivities.
- If your dog is debilitated, elderly, pregnant, nursing, or on other medications, please consult your veterinarian before using.
- If it seems to be irritating or causing other negative effects continue, or worsen, get veterinary assistance right away.
When handling the product, avoid contact with your eyes, skin and clothing as it may cause temporary eye irritation and is potentially harmful if swallowed or absorbed into the skin. Wash hands well after using and before eating, drinking, using chewing gum, tobacco or going to the bathroom. Launder soiled clothes before wearing them again.
What Other Drugs Can Affect K9 Advantix II?
K9 Advantix II is not considered to be highly likely to interact with other drugs if used properly. Combining more than one medicine simultaneously, however, can alter the way the medicines act or affect them or can make them more likely to have side effects. Prior to using K9 Advantix II, tell your veterinarian if your dog is taking any other product, including prescription medications, over-the-counter (OTC) drugs, vitamins, minerals, herbal products or dietary supplements.
Avoid using K9 Advantix II drug in combination with any other flea and tick control product unless directed by your veterinarian. Always check with your veterinarian when your dog is on any other medications or treatments to make sure it’s safe and right for your dog to use K9 Advantix II.
What Should I Avoid While Giving K9 Advantix II to My Dog?
K9 Advantix II is safe to use when applied to dogs but not to other animals. Only for use in dogs and puppies 7 weeks old or older, 4 pounds or more in body weight. Do not use K9 Advantix II on cats as they are not able to safely metabolize permethrin. If you have cats in your house, separate treated dogs from cats for approximately 24 hours to avoid any accidental exposure.
Seek veterinary advice immediately if a cat comes into contact with the product or grooms a dog which has been treated recently.
For safe application:
- Avoid eye and mouth contact with the product.
- Always use the correct dog size to apply treatment.
- Do not apply more than once every 30 days (once a month).
- Do not touch your eyes, skin or clothing when applying, as it may result in a temporary eye irritation and may be harmful if absorbed through the skin or swallowed.
- Wash hands with soap and water after use of the product and before eating, drinking, chewing gum, using tobacco or using the toilet. Wash soiled clothing prior to reusing.
If a person accidentally swallows the product, call a doctor or poison control center right away. If conscious, have them take sips of water; do NOT make someone vomit unless told to do so by a medical professional.
What Is the Most Important Thing You Should Know About K9 Advantix II?
K9 Advantix II is an over-the-counter (OTC) dog and puppy topical treatment and preventative for dogs 7 weeks or older, 4 pounds or more, and should only be used once per month. It features 8.8% imidacloprid, 44.0% permethrin and 0.44% pyriproxyfen which kill and repel fleas, ticks, mosquitoes, biting flies and chewing lice.
It also eliminates all life stages of flea infestations and offers protection against the major tick species such as Deer ticks, American dog ticks, Brown dog ticks and Lone Star ticks.
K9 Advantix II comes in weight-specific applicators, so make sure to select the specific product for your dog’s weight:
- 4–10 lbs: 0.014 fl oz (0.4 mL) – Green
- 11–20 lbs: 0.034 fl oz (1.0 mL) – Teal
- 21–55 lbs: 0.084 fl oz (2.5 mL) – Red
- Over 55 lbs: 0.135 fl oz (4.0 mL) – Blue
To keep you safe, keep product and the packaging out of the reach of children, wash your hands thoroughly after use and avoid contact with eyes, skin and clothing. If you have any allergies to the ingredients in the product, do not handle it. Use the proper product for the correct weight to prevent and control parasites in a safe and effective manner and be sure to follow label directions.
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FAQs
If I forget to use K9 Advantix II dose what should I do?
In the event of an application missed, apply K9 Advantix II at the time it is remembered and continue monthly applications from that date. Don’t double dose to compensate for the missed dose.
If too much K9 Advantix II dosage is applied, what should I do?
K9 Advantix II is well tolerated and is not likely to cause any overdose if it is used in the proper manner. However, please contact your veterinarian or an emergency veterinary clinic immediately if you suspect an overdose, your dog has ingested the product, or if your dog is displaying unusual symptoms.
How long last do K9 Advantix II?
Single use for up to 30 days protection against biting flies, chewing lice, fleas, ticks and mosquitoes. To get a constant protection use it monthly.
When does K9 Advantix II dog dosage start to work?
K9 Advantix II starts to work within hours of application and kills most fleas within 12 hours. The effect of new fleas that jump on your dog will last for at least 4 weeks, and the fleas will be killed in about 2 hours.
Is it okay to bathe my dog or let him swim after I use K9 Advantix II?
Yes. Your dog can be bathed or swim after 24 hours of drying. Regular bathing or swimming can shorten the time the product is fully effective.
What is the most times I can use K9 Advantix II in a month?
Should be used every 30 days routinely. Retreatment may be indicated if infestations are severe, but should not be used more frequently than once every 7 days unless advised by your veterinarian. Once the infestation is under control switch back to the monthly routine.
I’ve applied K9 Advantix II, but why are there still fleas?
Fleas can also jump onto your dog after treatment, if you have an infestation in your house or yard. K9 Advantix II quickly kills these newly acquired fleas, and you may notice dying fleas coming to the surface of your dog’s coat before they fall off.
Can I use K9 Advantix II on puppies and cats?
K9 Advantix II is only to be used for puppies and dogs, 7 weeks and older and 4 lbs or more. It is not suitable for use on cats as Permethrin is very toxic to them. Cats should also not be in contact with treated dogs for 24 hours.
How does the difference between K9 Advantix II formulas for small and large dogs?
The active ingredients and concentration in all weight-specific products are the same. The only difference is the amount of solution in each applicator, corresponding to the body weight of your dog, ensuring the correct dose.
Where to store K9 Advantix II medicine?
K9 Advantix II should be kept in the original container and protected from direct light until use, and at room temperature. Do not leave product where children and pets can reach it.
Key Takeaways
- K9 Advantix II is a topical, once-a-month treatment that wards off the threat of biting flies, chewing lice, mosquitoes, biting flies and ticks for your dog.
- It includes imidacloprid, permethrin and pyriproxyfen which act to kill and repel parasites on contact and stop the flea life cycle.
- Always use the correct K9 Advantix II dosage based on your dog’s weight with the use of a particular applicator for your dog’s body weight.
- It is effective in several hours, effective against most fleas in 12 hours and has 30 day protection.
- K9 Advantix II can be used in dogs and puppies 4+ lbs. and 7 weeks of age or older.
- Waterproof in 24 hours and can be used during regular bathing and swimming.
- There may be mild side effects like some skin irritation, itching or stomach upset that last for a short period of time. If there are severe or persistent reactions, contact your veterinarian.
- Permethrin is very toxic to cats; never use K9 Advantix II on cats. Treating dogs and cats separately and avoiding contact for 24 hours after the application.
- Do not use K9 Advantix II with any other flea and tick control product without consulting your vet.
- If protection against parasites is needed year-round, apply K9 Advantix II monthly, according to the product label directions.
Final Thoughts
K9 Advantix II Dosage For Dogs is a veterinarian-recommended topical formula that is trusted to protect dogs for 30 days against biting flies, chewing lice, fleas, ticks and mosquitoes with a single use. It kills and repels parasites on contact and interrupts the flea life cycle to keep your dog from irritation and from contracting flea-borne diseases before it is bitten.
To achieve optimal results, be sure to use the right K9 Advantix II dosage for your dog’s weight, apply once per month, and carefully follow all label instructions. Keep in mind that it is a dog product and not to be used on cats. Please consult your veterinarian before using K9 Advantix II with your dog if you have any questions about dosing, side effects or whether or not it is right for your dog.
