Effipro® Dosage Calculator for Dogs
Accurate Fipronil Spot-On dosage based on body weight
- Species Specificity: Designed for dogs only. Do not use on cats or rabbits.
- Application: Apply topically to the skin as directed by your veterinarian or product packaging.
- Minimum Effective Dose: Baseline requirement is 6.7 mg fipronil per kg (approx. 3.04 mg per lb).
Effipro Dosage for dogs is a quick onset, long lasting monthly treatment based on the principle of two active ingredients, Fipronil and Pyriproxyfen (PPF). These active ingredients work together to destroy adult fleas, flea eggs, flea larvae, ticks, chewing lice and help to stop the cycle of flea infestation.
It also has larvicidal activity against mosquitoes and some mites (including sarcoptic mites), and thus is a broad-spectrum parasite control agent.
Paid Links - As an Amazon Associate, I earn from qualifying purchases.
The topical product can only be used on puppies and dogs 8 weeks and older – Cats should NOT come into contact with this product, with exposure potentially being very dangerous and fatal. To safely and effectively protect your dog from parasites, you will learn the recommended dosage chart, how to administer it correctly, how often to use it, the benefits, potential side effects, safety precautions and answers to common questions regarding Effipro dosage for dogs.
What is Effipro Dosage For Dogs?
When using Effipro to dog, it is crucial to ensure that the correct dosage is applied to provide optimal protection from fleas and ticks, ensuring the safety and effectiveness of the treatment. Effipro Spot-On contains 10% fipronil (100 mg/mL) and has a minimum active dose of 6.7 mg of fipronil/ kg body weight (about 3.04 mg/lb).
The dosage is weight specific, so being able to measure your dog's weight correctly means that they will be given the exact amount to kill the parasites and not be under or over dosed, which can have negative consequences. Please ask a veterinarian for professional, personal advice before use, and apply Effipro topically to dogs only.
Effipro® Dosage Chart For Dogs By Weight
Here is the combined Effipro® dosage reference chart in a single table, showing both Imperial (lbs) and Metric (kg) weight benchmarks side by side:
| Weight (lbs) | Weight (kg) | Active Ingredient Target (mg) | Volume Required (mL) |
| 5 lbs | ~2.3 kg | 15.2 mg | 0.15 mL |
| 10 lbs | ~4.5 kg | 30.4 mg | 0.30 mL |
| 15 lbs | ~6.8 kg | 45.6 mg | 0.46 mL |
| 20 lbs | ~9.1 kg | 60.8 mg | 0.61 mL |
| 22 lbs | 10.0 kg | 67.0 mg | 0.67 mL |
| 30 lbs | ~13.6 kg | 91.2 mg | 0.91 mL |
| 40 lbs | ~18.1 kg | 121.6 mg | 1.22 mL |
| 44 lbs | 20.0 kg | 134.0 mg | 1.34 mL |
| 50 lbs | ~22.7 kg | 152.0 mg | 1.52 mL |
| 60 lbs | ~27.2 kg | 182.4 mg | 1.82 mL |
| 66 lbs | 30.0 kg | 201.0 mg | 2.01 mL |
| 70 lbs | ~31.8 kg | 212.8 mg | 2.13 mL |
| 80 lbs | ~36.3 kg | 243.2 mg | 2.43 mL |
| 88 lbs | 40.0 kg | 268.0 mg | 2.68 mL |
| 90 lbs | ~40.8 kg | 273.6 mg | 2.74 mL |
| 100 lbs | ~45.4 kg | 304.0 mg | 3.04 mL |
Important Notes:
- Concentration: Based on Effipro Spot-on 10% w/v (100 mg/mL fipronil).
- Baseline Formula: 6.7 mg/kg (3.04 mg/lb).
- Species Restricted: For topical use on dogs only.
What Is Effipro® Plus for Dogs?

Effipro® Plus Topical Solution for Dogs is a fast acting, long lasting monthly topical application for dogs and puppies 8 weeks or older. It is effective against adult fleas, eggs, larvae, ticks, chewing lice, and has mosquito and sarcoptic mite control.
Its active ingredients, fipronil and pyriproxyfen (PPF), not only kill existing parasites; they also prevent the development of flea eggs and larvae to help stop the flea lifecycle from continuing and help keep flea infestations to a minimum. Waterproof, UV resistant formula lasts up to 4 weeks and is effective after bathing, shampooing, swimming, water immersion and sun exposure.
Available in five convenient dose sizes for dogs that weigh 5 to 132 lbs. Don't use Effipro® Plus on cats, it can kill them.
What Else Should You Know About Effipro® Plus for Dogs?

Effipro® Plus is a waterproof, monthly topical treatment formulated to kill chewing lice, all stages of fleas and four types of ticks and to repel mosquito that could be carrying heartworm. It can be used to control and prevent parasites and is for use in dogs and puppies 8 weeks of age and older.
Effipro for dogs dosage is not to be used for cats. The product may be toxic to fish and wildlife, dispose of empty packaging and unused product as per local waste management.
Benefits of Effipro® Plus for Dogs

- Offers quick and extended protection (up to 4 weeks) against common external parasites.
- Kills adult flea, flea eggs, flea larvae, chewing lice and 4 types of ticks.
- Breaks the flea life cycle with pyriproxyfen (PPF) to help prevent future flea infestations.
- Helps protect against mosquitoes that could transmit heartworms.
- Provide monthly application to help control and prevent infestation by parasites.
- Waterproof and UV resistant, stays on even after swimming, water immersion, bathing, shampooing and sun.
- Simple-to-use topical solution for dogs 5-132 lbs., in 5 different weight ranges.
- For use in dogs and puppies 8 weeks of age or older, as long as directed.
Directions for the use of the Effipro® Plus for dogs
Effipro® Plus is for external use only on dogs and puppies 8 weeks of age or older that weigh at least 5 lbs. Always read through the label thoroughly prior to every application and carefully adhere to the directions and precautions. Always weigh your dog before administering to make sure you are giving the right amount for that weight, it can make your dog very sick if you give too much.
If your dog is suffering from a skin disorder, or is under treatment for one, talk to your vet before using any topical flea and tick product.
To apply, first remove the applicator from the package, then break the seal with the cap, part the hair between your dog's shoulder blades and squeeze the contents of the applicator directly onto the exposed skin.
Effipro® Plus Ingredients
- Fipronil (9.78%) – This insecticide is effective against adult fleas, ticks and chewing lice.
- Pyriproxyfen (2.94%) – Insect growth regulator (IGR) which blocks the development of the flea egg and larval stages, thus interrupting the flea life cycle and minimizing further flea infestations.
- Glycol Ether (80–90%) – Serves as the carrier ingredient to evenly disperse the active ingredients over the skin to provide effective topical protection.
You May Also Like to Read:
- Duralactin Dosage For Dogs: Calculator, Chart & Safe Guide
- Droncit Dosage For Dogs: Calculator, Safe Guide & More
FAQs
What are the possible issues that my dog may encounter with Effipro® Plus?
In some cases, dog may have slight irritation at the application site. Consult your veterinarian before giving your dog Effipro® Plus if your dog is already receiving treatment with other medications or supplements. Avoid application to rabbits or other small mammals, due to possible toxicity.
Paid Links - As an Amazon Associate, I earn from qualifying purchases.
How do you use Effipro® Plus?
Once a month, put Effipro® Plus medication directly onto your dog's skin following the instructions on the product. Thoroughly wash your hands after every use.
What do the ingredients of Effipro for dogs solution do?
Effipro® Plus contains two active ingredients: Fipronil, which kills fleas and ticks, and Pyriproxyfen, which can help prevent flea eggs and larvae developing.
May Effipro® Plus be used in conjunction with other drugs?
Please inform your veterinarian of any other medications or supplements that your pet is taking to make sure that Effipro® Plus is right for your dog.
Can Effipro® Plus be used with other medications?
Yes. Effipro® Plus is a brand product and the brand ordered will be provided.
Does my dog have to administer Effipro® Plus for the entire recommended course?
Treatment can last for as long as necessary to ensure your dog is protected from parasites. If you have any questions about the duration of use of Effipro® Plus, please ask your veterinarian.
After applying Effipro dosage for dogs, should I wash my dog?
Apply the treatment once a month, according to the directions on the product label. After application wash hands and leave on dog's skin as directed.
Are there other pets other than dogs which Effipro® Plus can be used on?
Effipro® Plus is only for use in dogs. It is possibly toxic to rabbits and other small mammals, and should not be used on cats if it is designed for use on dogs.
Key Takeaways
- Effipro is a once-a-month topical treatment for puppies and dogs 8 weeks of age and older that weigh 5 lbs. or more.
- It is thought to eliminate adult fleas, flea eggs, flea larvae, chewing lice, and four types of ticks and to repel mosquitoes.
- Active ingredients include fipronil (9.78%) and pyriproxyfen (2.94%) that are effective in interrupting the flea life cycle and preventing re-infestation.
- The waterproof, UV-resistant formula is effective on its own for up to 4 weeks even after swimming, shampooing, bathing or sun exposure.
- Use the correct dose, depending on the person's weight, directly on the skin between the shoulder blades once a month.
- There may be slight skin irritation at the site of application. Ask your veterinarian if your dog has any skin issues, or is on any other medications or supplements.
- Avoid use on cats, rabbits or other small mammals because the dog formulation can be harmful to these species.
- Before using, carefully read and follow the directions on the product label, and dispose of unused product and packaging in a manner prescribed by local waste management guidelines to reduce impacts to fish and wildlife.
Final Thoughts
Effipro dosage for dogs is an easy-to-use topical product that offers complete protection against fleas, ticks, chewing lice and mosquitoes in dogs and can be administered on a monthly basis. It contains two active ingredients: fipronil and pyriproxyfen, which will not only kill the fleas that are there, but help prevent future flea infestations by interrupting the flea life cycle.
When properly used and as directed on the product label, it provides waterproof, long-lasting protection for up to 4 weeks. Please follow the instructions for use carefully, and use the correct weight based dose, and consult your veterinarian if you have any doubts or concerns about using Effipro® Plus in your dog.














