Clonidine Dosage For Dogs Calculator
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Disclaimer: This guide is for informational purposes only and is not a substitute for professional veterinary advice.
Always consult your veterinarian before giving Clonidine or any medication to your dog.
If your dog hides under the bed when there is thunderstorm, trembles when he hears the sound of fireworks, or is destructive when he is left alone, then you probably are finding the solution to ease him of the fear.
Clonidine Dosage For Dogs, a drug used for the treatment of high blood pressure in humans, has become an important tool in the veterinary behavior field for the treatment of anxiety and fear based behaviors in dogs.
This is the definitive guide to include Clonidine Dosage For Dogs calculator by weight, detailed Clonidine Dosage For Dogs charts per kg or lb, safety of cloning and answering the most common questions the pet dog owners have regarding this medication.
Finding the right clone size for dogs involves looking at the weight of your dog, as well as the problem you are trying to treat them for, and how their personal bodies respond to medication.
A clonidine dosage for dogs calculator per pound or kg is handy for interpreting veterinary recommendations and converting them into proper measurements, but should never be used besides the advice of a veterinary specialist.
Throughout this article, we will explored the understanding the proper use of clonidine dosage for dogs calculator, a correct dosage range for canine patients, as well as when this medication can be appropriate for your furry friend.
Before we get into the details, it is imperative that you have to understand that clonidine is prescribed off-label for dogs.
This means that this has not been approved by the U.S. Food and Drug Administration for veterinary use specifically, but vets with experience in behavior medicine have used it safely and effectively for years now.
Any use of clonidine dosage for dogs calculator by weight (kg or lb) under veterinary supervision should be done under veterinary supervision.
Key Takeaways
- Clonidine Dosage For Dogs is an Alpha-2 Adrenergic agonist, which has an anxiolytic effect by blocking the release of norepinephrine in the brain, which effectively calms the "fight or flight" response.
- The typical Clonidine Dosage For Dogs is between 0.01 to 0.05 mg per kg of the weight of the animal, and given every 8 to 12 hours as needed or regularly.
- A clonidine dosage for dogs calculator is helpful to determine the proper dosage for the dog depending on the weight, but starting to the lower end of the range and adjusting as directed by a veterinarian is recommended.
- Clonidine Dosage For Dogs is usually used for separation anxiety, noise phobias (thunderstorm, fireworks), fear based aggression and situational anxiety such as going to the vet.
- The most common side effects are sedation, dryness in the mouth (increased drinking/ lip smacking), constipation, and rarely, agitation or paradoxical excitement.
- Clonidine Dosage For Dogs by weight is most effective if taken 60 to 90 minutes before being exposed to a stressful event and typically lasts between 4 and 6 hours.
- This medication is to be used with caution in dogs with heart disease, kidney disease or liver disease and should not be used with some other medication forms without veterinary approval.
What is Clonidine Dosage For Dogs and How Does It Work?

Clonidine belongs to a class of drugs called alpha-2 adrenergic agonists. To get an idea of how it works, let's say that in your dog, there was a volume dial to the level of stress that they had in their brain.
When your dog is scared, i.e. by a loud thunderclap, by a stranger approaching or being left alone, their brain releases a neurotransmitter called norepinephrine, which works like adrenaline.
This produces the "fight or flight" response, where one will see that your dog's heart rate increases, blood pressure rises, the muscles tense up and your dog becomes alert and reactive.
Clonidine Dosage For Dogs basically turns the volume down on that. It binds to alpha-2 receptors in the brain, and prevents the release of norepinephrine that could get the stress response out of hand.
By calming the arousal center of the brain before the anxiety would have taken hold, Clonidine Dosage For Dogs helps your dog to be more relaxed and able to deal with stressful situations.
Research has shown that effects of clonidine are mediated through the postjunctional stimulation of the alpha-2 adrenoceptors in dogs and plays an important role in the vascular responses.
While this mechanism was researched principally in relation to blood pressure, it can help to explain the fact that clonidine has such effective calming effects in dogs of anxiety.
Unlike some anti-anxiety drugs which can take weeks to have their full impact, clonidine works fairly quickly. Usually, if taken 60 to 90 minutes before a stressful event, its sedative effects begin within one to two hours and then persist for four to six hours.
This makes it especially useful for predictable types of stress like thunderstorms, fireworks or visits to the veterinarian's office.
Uses Of Clonidine Dosage For Dogs

Veterinary behaviorists as well as general practitioners use clonidine to treat a number of fear-based and anxiety-related conditions.
Understanding when to use a clonidine dosage for dogs calculator per day starts with understanding what is this medication used to treat.
Separation Anxiety
Dogs with separation anxiety become disrupted when they have to be left to their own devices, and will often bark excessively, destroy furniture, eliminate indoors, or make an effort to escape.
Clonidine Dosage For Dogs can be helpful in getting these dogs to be calm when the owner is not present, especially used with other longer acting drugs such as fluoxetine (Prozac) or clomipramine (Clomicalm).
For separation anxiety, clonidine is usually administered before the owner leaves and can be administered on a daily basis or on a situational basis.
Noise Phobias
Thunderstorms, fireworks, and other loud noises are some of the most common stressors and causes for canine anxiety. Many dogs will get terrified, pant, pace, hide or try to escape.
Clonidine Dosage For Dogs has become known as a great choice in noise phobias.
In fact, famous veterinary behaviorist Dr. Nicholas Dodman has labelled clonidine his "new favorite secret weapon" in the treatment of storm phobias in favor of alprazolam (Xanax) because of less paradoxical reactions and non-addictive qualities.
Fear-Based Aggression
Some dogs lash out of fear - at strangers, at other dogs or even at family members under certain circumstances. Fear-based aggression may be dangerous and stressful for all involved.
Clonidine Dosage For Dogs helps to reduce the dog's general level of arousal making them less reactive to triggers and more responsive to behavior modification training.
Leash Reactivity
The dogs that lunge, bark and growl at other dogs or people on a leash, are often doing so out of fear and frustration.
Clonidine can be given before walks to reduce reactivity and hence more positive training experiences can be had.
Situational Anxiety
Veterinary visits, grooming appointments, car rides and travel are very stressful experiences to many dogs. Clonidine can be used on an as needed basis for helping anxious dogs deal with these necessary but stressful events.
Adjunct Therapy
Perhaps most of all, Clonidine Dosage For Dogs often is one of the drugs used as an add-on.
Many dogs with severe anxiety do well with a combination approach; a daily longer acting medication such as fluoxetine or clomipramine to help with the baseline anxiety and clonidine for the break through anxiety or predictable stressors.
Because clonidine has a different mechanism of action than these other medications, the combination of these medications often results in better effects with no increase in side effects.
Precautions and Side Effects
Every medication carries the possibility of risk and clonidine is no exception.
While generally this medication is well-tolerated, it is important to understand the potential side effects and precautions that come along before using a clonidine dosage for dogs calculator.
Common Side Effects
The most reported side effect is sedation. Since clonidine is supposed to help to calm down the brain, some dogs may become too sleepy or lethargic, especially on the first day of being on the drug or at larger doses.
This usually is mild and many times diminishes as the dog adapts to the drug. If you feel it is too much to be sedated, your veterinarian might be able to reduce.
Dry mouth is another side-effect which is known or known. In dogs, this may manifest itself by increased water consumption, lip smacking or seeking out water more frequently than normal.
While they are not harmful, it is something to be observed.
Constipation may be a problem in some dogs. Ensuring sufficient hydration and monitoring the bowel movements will help control this side effect.
Less common, but possible side effects are:
- Lack of coordination/ unsteadiness
- Agitation or paradoxical excitement (opposite of calming that you want to have)
- Decreased heart rate
- Lowered blood pressure
When Is Clonidine Contraindicated?
Clonidine is not all dogs. According to veterinary sources, the following are the precautions:
Heart disease: Since clonidine has an effect on heart rate and blood pressure, it should be used cautiously in patients with pre-existing cardiovascular diseases.
Your veterinarian will make the decision as to whether the benefits outweigh the risks.
Kidney or liver disease Dogs with poor kidney or liver function may have a slower rate of processing clonidine and therefore may experience prolonged response times or higher risk of side effects. Dosage changes may be necessary.
Hypersensitivity Dogs with known allergies to clonidine or medications that are similar to clonidine should not be given it.
Pregnancy and nursing: Clonidine can traverse the placenta and cross the breast milk. The risk vs. benefit needs to be carefully considered by your veterinarian.
Drug Interactions
Clonidine interacts with several other drugs. It is important to inform your veterinarian of all the medicines (prescription drugs, over-the-counter products and supplements) your dog receives.
Some of the significant interactions are:
- Other alpha 2 agonists such as Sileo (dexmedetomidine)
- Monoamine oxidase inhibitors (MAOIs) Anipryl (selegiline)
- Beta-blockers and calcium channel blockers- for heart problems
- Tricyclic anti-depressants such as amitriptyline and clomipramine
- Other sedative drugs and tranquilizers
- Some of the antibiotics including sulfamethoxazole/trimethoprim
Combining clonidine with these medications can lead to excessive sedation, potentially dangerous falls in blood pressure or other effects.
What To Do About Side Effects
If your dog is suffering mild side effects such as sedation, call your veterinarian for advice. He or she may alter the dose or timing.
If you start to notice some signs of agitation, aggression or any symptoms of concern, stop the medication and contact your veterinarian right away.
In case of overdose or bad reaction, then immediately call an emergency veterinary facility.
Dosing Information Of Clonidine Dosage For Dogs
Accurate dosing is very critical in the use of Clonidine Dosage For Dogs. A clonidine dosage for dogs calculator by dog weight is helpful for being precise but knowing the principles behind things will help you be a better advocate for your pet.
General Dosing Principles
Clonidine Dosage For Dogs is usually based on the kilo of body weight. A normal therapeutic range for behavioral indications in the dog is 0.01 to 0.05 mg/kg of body weight every 8 to 12 hours.
For the sake of reference 1mg is equivalent to 1000 micrograms (mcg) so precision is important when measuring.
The "start low, go slow" technique is standard. Most veterinarians will start at the lower end of the range (0.01 mg/kg) and gradually work their way towards the other end depending on how the dog is responding to it, as well as how well they are tolerating the drug.
This allows you to know what is the smallest effective dose used for controlling anxiety without being too sedated.
Taking A Calculating Clonidine Dosage For Dogs
This clonidine dosage for dogs calculator makes it easier.
In order for one to be used effectively you need:
- Your dog's appropriate weight in kilos or pounds
- The prescribed dose in mg/kg
- The strength of tablets you have (common strengths are 0.025mg, 0.05mg, 0.1mg and 0.2mg tablets)
To convert Pounds to Kilograms we need to divide by 2,2. One example of this is that an animal which weighs 40 pounds is equal to 18.2 kilograms.
Clonidine Dosage For Dogs Chart By Weight
The following clonidine dosage for dogs chart per kg or lb provides estimated dosages based on the normal dose range of 0.01 to 0.05mg/kg.
Remember that your veterinarian will know how much to start with and they may change the dose over time.
| Dog Weight (lbs) | Dog Weight (kg) | Low Dose (0.01 mg/kg) | Moderate Dose (0.03 mg/kg) | High Dose (0.05 mg/kg) |
|---|---|---|---|---|
| 5 lbs | 2.3 kg | 0.023 mg | 0.07 mg | 0.115 mg |
| 10 lbs | 4.5 kg | 0.045 mg | 0.135 mg | 0.225 mg |
| 15 lbs | 6.8 kg | 0.068 mg | 0.204 mg | 0.34 mg |
| 20 lbs | 9.1 kg | 0.091 mg | 0.273 mg | 0.455 mg |
| 25 lbs | 11.4 kg | 0.114 mg | 0.342 mg | 0.57 mg |
| 30 lbs | 13.6 kg | 0.136 mg | 0.408 mg | 0.68 mg |
| 35 lbs | 15.9 kg | 0.159 mg | 0.477 mg | 0.795 mg |
| 40 lbs | 18.2 kg | 0.182 mg | 0.546 mg | 0.91 mg |
| 45 lbs | 20.5 kg | 0.205 mg | 0.615 mg | 1.025 mg |
| 50 lbs | 22.7 kg | 0.227 mg | 0.681 mg | 1.135 mg |
| 55 lbs | 25.0 kg | 0.25 mg | 0.75 mg | 1.25 mg |
| 60 lbs | 27.3 kg | 0.273 mg | 0.819 mg | 1.365 mg |
| 65 lbs | 29.5 kg | 0.295 mg | 0.885 mg | 1.475 mg |
| 70 lbs | 31.8 kg | 0.318 mg | 0.954 mg | 1.59 mg |
| 75 lbs | 34.1 kg | 0.341 mg | 1.023 mg | 1.705 mg |
| 80 lbs | 36.4 kg | 0.364 mg | 1.092 mg | 1.82 mg |
| 85 lbs | 38.6 kg | 0.386 mg | 1.158 mg | 1.93 mg |
| 90 lbs | 40.9 kg | 0.409 mg | 1.227 mg | 2.045 mg |
| 95 lbs | 43.2 kg | 0.432 mg | 1.296 mg | 2.16 mg |
| 100 lbs | 45.5 kg | 0.455 mg | 1.365 mg | 2.275 mg |
Note: These are estimated doses one must take according to weight. Actual paced prescribed doses may vary depending on individual factors, concomitant medication and veterinary assessment.
Administration Guidelines
Clonidine Dosage For Dogs is usually administered as a pill that is taken by mouth.
It could be given with or without food but if your dog has vomiting or appears to be having nausea issues after taking it on an empty stomach, try feeding it a small meal or treat with the next dose.
For situational use, of Clonidine Dosage For Dogs about 60 to 90 minutes before the expected stressful event. This leaves time for absorption and onset of effects before anxiety triggers take place.
For highly agitated dogs, the medications may not be as helpful and effective when already agitated, so time is everything.
For dogs that need to be managed for anxiety on a daily basis, clonidine is usually administered twice a day, about every 12 hours.
What If You Miss A Dose?
If you miss a dose, give it just as soon as you remember. However, if it is close to being time for the next scheduled dose, then skip the missed dose and take the regular schedule.
Never give two doses in one time or double doses.
How To Use The Clonidine dosage for dogs Calulator
Using clonidine dosage for dogs calculator will appropriately allow accuracy and safety. Here is a step-by-step guide:
- Weigh your dog accurately: Use the scale digitally if possible. If you do not have a scale your veterinarian will be able to tell you an accurate weight.
- Convert weight in kilograms: if necessary If your calculator needs expressions in kilos, divide pounds by 2.2.
- Know your prescribed dose: Your veterinarian will give you a dosage in mg/kg. Common starting doses are 0.01 mg/kg with increases of up to 0.05 mg/kg as is required.
- Calculate the total dose: You can multiply your dog's weight in Kg by the required dose in mg/kg according to the package to calculate the exact required dose. This gives the number of milligrams required in total.
- Determine tablet strength: Clonidine Dosage For Dogs tablets are available in different strengths. Your veterinarian will prescribe a proper strength. Common strengths are 0.025mg, 0.05mg, 0.1mg, and 0.2mg tablets.
- Verify the dose: Verify your calculations - double check your calculations. If in doubt, contact your veterinarian for confirmation then administer.
Example: A 40-pound dog weighs 18.2 kg. If prescribed 0.03 mg/kg; the total dosage is 0.546 mg. This could be administered by means of a 0.5 mg tablet or a combination of smaller tablets.
What Are The Most Serious Risks Of Clonidine to Dogs?

While clonidine is often thought to be a safe drug to use, when all appropriate regulations are followed, there are risks that need knowledge.
The most serious possible risks are:
Paradoxical Excitation
In some dogs, clonidine may have the opposite effect to the desirable one. Instead of calming the dog, it can make the dog more agitated, anxious or even aggressive.
This is more common with alprazolam (Xanax) but may occur with clonidine as well. If you perceive your dog becoming more anxious, restless or reactive following the receiving clonidine, then call your veterinarian.
Cardiovascular Effects
Due to clonidine's action of decreasing the blood pressure and heart rate, dogs with heart disease may be at greater risk.
Severe hypotension (dangerously low blood pressure) or bradycardia (excessively slow heart rate) may result, especially if overdosing or to persons who are sensitive to them.
Overdose
Clonidine Dosage For Dogs overdose can lead to severe sedation, dangerously low blood pressure, slowed heart rate, slowed breathing and even coma.
So if you have reasons to suspect an overdose, due to either ingestion of several tablets by accident, or because you've just made a simple error in calculations (for example, by using a clonidine dosage for dogs calculator) seek emergency veterinary care immediately.
There are a number of signs of overdose, one of which is extreme lethargy, trouble in waking, shallow breathing, pale gums, or collapse.
In cases of significant overdose, activated charcoal, intravenous fluids, monitoring the heart rate, and use of medications to support the blood pressure may be undertaken by the veterinary profession.
Withdrawal Effects
If clonidine has been used long-term and it is abruptly stopped some dogs may suffer withdrawal effects which include a rapid increase in blood pressure, anxiety and agitation.
This is why it is important to taper the dose slowly with veterinary advice so that it is not suddenly stopped.
Ideal Uses Of Clonidine Dosage For Dogs
Clonidine does well in certain situations. Understanding at what time it is most effective for the person can help with establishing these realistic expectations.
Predictable Stressors
Clonidine For Dogs Dosage is great for expected situations. Fireworks on the Fourth of July, an impending thunderstorm, a scheduled vet visit or a trip that was planned - these all are prime times to use clonidine proactively.
Administration of the medication 60 to 90 minutes before the procedure gives the medication time to become effective before the stress response occurs.
Combination Therapy
Many dogs that suffer from severe anxiety need more than one medicine.
Clonidine is often taken in combination with some of the longer acting medications such as fluoxetine (Prozac) or clomipramine (Clomicalm) for both base line stability and breakthrough coverage.
This combination approach often produces better results than any medication on its own, however.
Medications Dogs That Do Not Respond To Medications Of First Choice
Not all dogs respond to the drugs tracerone, gabapentin or fluoxetine.
For those dogs who have tried these medications and not gotten proper relief, clonidine is an alternative mechanism of action that may provide the calming effect they are seeking.
Situations Kaenging Nanl Stories
Unlike medications meant to be taken daily, which take weeks to work to maximum efficiency, Dosage of Clonidine For Dogs works within an hour to two hours.
This makes it ideal for situations where you need fast acting anxiety relief instead of waiting for long term, building up medication to kick in.
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FAQs
Can I use a clonidine dosage for dogs Calculator for any size dog?
Yes, a clonidine dosage for dogs calculator works for any size dog as the dose is based on the weight. However, very small dogs (under 5 pounds) must be given very precise doses and it may be necessary to split tablets.
Your veterinarian can help establish if clonidine is suitable with small breeds/breed toys.
How Often Can I Give Famidine to My Dog.
For situational use, clonidine can be administered 8 to 12 hours as-needed. For daily management it is usually administered twice daily.
Your veterinarian will determine the frequency at which your dog should be vaccinated and supplement towards their illness.
How-long does it take for clonidine to work in dogs?
Clonidine usually works after 60 to 90 minutes when it is taken by mouth. For best results administer it before the stress response sets in.
Can I give landmark or bout of clonidine and traces to my dog?
Clonidine and Trazodone are sometimes used together under veterinary supervision especially for severe levels of anxiety or veterinary visitation.
However, the use of combination sedatives puts people at risk for taking too much sedative and for having a drop in blood pressure. This is a combination that should only be used according to the directions from your veterinarian.
What do I do if my dog vomits because of clonidine?
If your dog vomits soon after he gets the medication, contact your veterinarian for instructions.
They may advise waiting and giving another dose or they might suggest giving the next dose with food to minimize the stomach upset.
is Clonidine For Dogs Dosage safe for long term use for dogs?
Clonidine can be used on a long-term basis in dogs with chronic anxiety disorders.
However, regular changes and check-up on blood pressures by your veterinarian are recommended for dogs who are under chronic therapeutic drugs.
Can I use clonidine prescription for my dog instead?
Never give your dog medicine prescribed to you or anyone else. Human dosages are different and other ingredients in the formulation may be harmful to dogs.
Always use veterinary prescribed clonidine.
What happens if my dog accidentally overdoses on clonidine?
If you think there is an overdose, seek veterinary help immediately. Slowed breathing, difficulty in waking, slowed breathing, and low body temperature are some of the signs.
Bring with you the bottle of medication to be sure of exactly what was ingested by the pet.
Final Thoughts
Clonidine For Dogs Dosage By Weight is a useful option for dogs with issues with fear-based anxiety, noise phobias and situational stress.
When used correctly and under veterinary supervision with a good clonidine dosage for dogs calculator by dog weight, this drug can have a major impact on the quality of life of the anxious dog and its anxious owner.
Remember that the medication is most successful when it is combined with behavior modification, training and environmental management.
Clonidine For Dogs Dosage helps to calm down the brain to allow your dog to learn the new coping skills and respond to training efforts.
It is not a cure for but rather a tool to help your dog navigate a world that can sometimes be too overwhelming.
Every dog is affected differently by medication. What is a perfect fit for one dog may have to undergo modification for another.
Patience, close observation, and communication with your veterinarian are important features of successful treatment.
Do not hesitate to ask questions, report side effects or notice issues about your dog's response to clonidine.
If you are interested in using clonidine for your dog, do consult your veterinarian or a veterinary behaviorist.
They will so check your dog health they will also discuss some possible at risks or benefits and help you to determine appropriate starting dose.
With the proper approach, clonidine may be the solution your anxious buddy needs to find the calm they deserve.







